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Hypersensitivity reaction season is here, and over-the-counter hypersensitivity reaction medicate s are flying off the shelves. But did you know that mixing certain hypersensitivity reaction medicate s with otherness medicines can have hazardous effects on your health?

The active ingredients of hypersensitivity reaction products can cause over-medicating with otherness combination or single-entity non-prescription or prescription medicate s.

“By consulting with your pharmacist, consumers can make an educated choice as to which hypersensitivity reaction medicine is right for them,” says Dr. Daniel A. Hussar, Remington professor of medicine at Philadelphia College of Pharmacy at University of the Sciences in Philadelphia. “Consumers should read the warnings on over-the-counter medicines and consult with their pharmacist in order to make educated decisions about which hypersensitivity reaction medication is right for them.”

“Certain hypersensitivity reaction medicate s (antihistamines) can cause drowsiness or sleepiness, and caution must be observed when participating in activities like driving or operating machinery,” Hussar noted. If this response is bothernesssome, the consumer should ask the pharmacist to recommend a product that does not cause this sedative effect.

Some antihistamines have a drying effect and cause annoying effects like dry mouth. “This is anotherness situation in which the pharmacist can recommend anotherness product that is not likely to cause this effect.”

Some hypersensitivity reaction products contain analgesics such as acetaminophen or ibuprofen. When an hypersensitivity reaction product containing one of these analgesics as a secondary ingredient is taken by a patient who is also using an analgesic for anotherness purpose, an excessive response may result. Side effects may be subtle and develop slowly but, in some individuals serious stomach, kidney, or liver problems could result.

Some patients with high blood pressure may experience problems due to the decongestants included in many hypersensitivity reaction products. Decongestants can raise blood pressure, which can be particularly dangerous in patients with high blood pressure that is not well controlled, says Hussar.

Dr. Hussar has been quoted and has published extensively on issues surrounding consumer-related medicine practices. Dr. Hussar is available for interviews.

University of the Sciences in Philadelphia is a private, coeducational institution founded in 1821 as Philadelphia College of Pharmacy, the first college of medicine in North America. It is where the founders of six of the top pharmaceutical companies in the world launched their futures. Comprising four colleges across a broad range of majors, USP specializes in educating its 2,800 students for rewarding careers through its undergraduate, graduate, and doctoral degree programs in medicine , science, and the health sciences.

University of the Sciences in Philadelphia
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Researchers from Mayo medical institution have discovered that allergic rhinitis is associated with the development of Parkinson’s illness later in life. Findings will be published in the Aug. 8 issue of the journal Neurology.

“The association with Parkinson’s illness is increased to almost three times that of someone who does not have allergic rhinitis,” says James Bower, M.D., Mayo medical institution neurologist and lead meditate investigator. “That’s actually a pretty high elevation.”

Previous studies had shown that group who regularly take nonsteroidal anti-inflammatory medicate s, such as ibuprofen, are less likely to develop Parkinson’s illness. These results prompted the Mayo medical institution investigators to look further into the links between illnesss characterized by inflammation and Parkinson’s. They studied 196 group who developed Parkinson’s illness, matched with group of similar age and gender who did not develop Parkinson’s. The meditate was conducted in Olmsted County, Minn., home of Mayo medical institution , over a 20-year period.

The researchers examined these groups to determine if those who developed Parkinson’s illness had more inflammatory illnesss. They found that those with allergic rhinitis were 2.9 times more likely to develop Parkinson’s. They did not find a similar association between inflammatory illnesss such as lupus, rheumatoid arthritis, pernicious anemia or vitiligo and Parkinson’s illness. The researchers hypothesize that they may not have found significant links between these illnesss and Parkinson’s illness due to the relatively small number of those in the population who have these illnesss, and thus the small number with these illnesss in their population sample meditate . They also did not find the same association with Parkinson’s illness in patients with asthma that they discovered in those with allergic rhinitis.

Dr. Bower says that this meditate did not examine patients’ types of allergies or when they developed allergies.

The investigators theorize that a tendency toward inflammation is the key link between the illnesss.

“People with allergic rhinitis mount an immune response with their allergies, so they may be more likely to mount an immune response in the brain as well, which would produce inflammation,” Dr. Bower says. “The inflammation produced may release certain chemicals in the brain and inadvertently kill brain cells, as we see in Parkinson’s.”

Dr. Bower explains that this meditate does not prove that allergies cause Parkinson’s illness; instead, it points to an association between the two illnesss. He advises that hypersensitivity reaction patients can do little to reduce the potential risk for Parkinson’s.

“I wouldn’t worry if you have allergies,” he says. “Treat the hypersensitivity reaction syndromes you have to alleviate them at the time. At this point, we have no good evidence that this pharmacomedical care will protect you from possibly developing Parkinson’s illness later.”

Dr. Bower and colleagues hope, however, that the clues in this meditate may give scientists a strong hint about inflammation’s role in Parkinson’s.

“This is exciting, because we may be able to develop medicate s to block the inflammation,” he says.

Parkinson’s is a complex illness, says Dr. Bower, because many factors can contribute to its development and its causes can differ. The complexity can be compared to heart attacks, which can be caused by cardiovascular disease , high cholesterol or smoking, among otherness factors. Thus, allergic rhinitis would now be considered one among many possible risk factors for development of Parkinson’s illness.

Parkinson’s illness affects nerve cells (neurons) in the part of the brain that controls muscle movement. People with Parkinson’s illness often experience trembling, muscle rigidity, difficulty walking, and problems with balance and coordination. These syndromes generally develop after age 50, although the illness also affects a small percentage of younger group. The normal lifetime risk to develop Parkinson’s illness for men and women combined is 1.7 percent.

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Drug experts have warned parents and healthcare professionals to double-check if children with allergic conditions such as asthma and hayfever are being over-prescribed corticosteroids. The warning follows research unveiled at the British Pharmaceutical Conference (BPC) in Manchester revealing that many children with multiple allergic conditions such as asthma, eczema and hayfever may be exposed to high, cumulative doses of corticosteroids through co-prescribing of steroid preparations for difference conditions.

Asthma and hayfever are common conditions in children for which long-term inhaled or nasal corticosteroids may be prescribed. Some children with severe conditions may receive both, resulting in high doses of steroids and increased risk of adverse effects.1

An audit of 304 general practices carried out by researchers from Aberdeen University, including the records of 345,221 children, found that almost 9percent of all children issued with a repeat prescription for an inhaled corticosteroid for asthma were also prescribed at least one otherness steroid preparation such as nasal corticosteroids.

Lead researcher Dr James McLay, Senior Lecturer in the Department of Medicine and Therapeutics at Aberdeen University, said: “This research shows that a significant number of children are prescribed more than one corticosteroid preparation for an allergic condition.

“If a child is prescribed corticosteroid medical care for one condition at the maximum or near the maximum dose, then anotherness steroid prescription would tip them into over-exposure.”

Dr McLay suggested that GPs may not always recognise that a child is potentially over-exposed to corticosteroids because general practice systems may not be set up to alert them to the impact of cumulative corticosteroid dosing, particularly if prescriptions are issued on a repeat basis. He said: “While this meditate did not set out to identify individual children receiving too high doses of steroids, our data suggests that up to 50percent of children prescribed an inhaled and nasal corticosteroid, together, could be receiving too high a cumulative dose of steroid.

“We therefore recommend that all healthcare professionals or parents under the direction of a healthcare professional check for this issue,” added Dr McLay.

The potential long-term toxicity of chronic corticosteroid use in children is unclear, but there have been concerns about the impact on child growth. However, most children with asthma eventually attain normal height, even after receiving moderate corticosteroid doses.2, 3

Dr McLay said: “Corticosteroids have revolutionised the medical care of asthma and probably saved many children’s lives. But against a background of concern about the impact of long-term corticosteroid use, this meditate suggests that GPs should always consider the potential cumulative steroid burden for an atopic child.”

The British Pharmaceutical Conference - entitled “The medicines maze: balancing risks and benefits” - takes place from 10th to 12th September, 2007, at Manchester Central (formerly Manchester International Convention Centre). The theme of BPC 2007 is reflected throughout the programme, with keynote speeches and workshops addressing crucial technical and professional issues that are facing medicine today. The conference will showcase the laagsdhfgdf developments in pharmaceutical science and practice research and include discussion and debate led by expert speakers.

References

1. Ekins-Daukes S, et al. Burden of corticosteroids in children with asthma in primary care: retrospective observational meditate . BMJ 2002;324:1374.

2. Patel L, et al. Symptomatic adrenal insufficiency during inhaled corticosteroid medical care. Arch Dis Child 2001;85:330-334.

3. Agertoft L, Pedersen S. Effect of long-term medical care with inhaled budesonide on adult height in children with asthma. NEJM 2000;343:1064-1069.

Royal Pharmaceutical Society of Great Britain

Mealtime should be an enjoyable experience. Yet, for 12 mil. children with food allergies, eating a meal can be a frightening activity. For some of these children, even the slighagsdhfgdf exposure to the wrong food can be deadly.

Heidi Roehrig is the motherness of a 4-year old boy with nut allergies. A year ago, her son had a severe allergic reaction after eating trail mix with nuts.

“Our life has changed incredibly. Suddenly we’re afraid of play dates and birthdays. These should be fun you want them to be fun for your child but we’re fearful of not being able to control all the foods,” says Roehrig.

In the Roehrig family, simple summer pleasures like going to the ice cream parlor don’t take place anymore. Too many of the ice creams contain nuts, and the family has no way of knowing if surfaces and tools have been cleaned correctly.

“There are lots of things that just aren’t enjoyable anymore because we can’t feel confident that our son isn’t going to have a reaction. Even grocery shopping is a huge ordeal you have to read the label on everything, including foods you buy every week, because you never know when it’s going to change,” she says.

The impact of food allergies on the family is tremendous. For the families of children who have developed severe food allergies, it alters every aspect of life, whether it’s babysitters, daycare, visiting family and friends, even going to the doctor’s office.

The process of diagnosing food allergies, though welcome, also poses its own problems. Testing children with serious food allergies can be an extremely stressful and even dangerous situation. These concerns have prompted the University of Michigan Health System to create an innovative Food Allergy medical institution that offers families a safe and relaxing facility to agsdhfgdf or challenge for food allergies. It was designed specifically to provide a safe environment for hypersensitivity reaction experts to evaluate and treat patients with food allergies.

“We have built a controlled area where children can come to be evaluated and diagnosed. The resulting data allow us to develop what we call a ‘challenge.’ In most of our challenges, we introduce a food that we believe can be tolerated now that the child is older. We can also do airborne challenges to see if a child will have an allergic reaction to a smell, such as to peanuts,” explains Marc McMorris, M.D., medical director of the clinic and clinical associate professor of internal medicine and pediatrics.

Because some food allergies, including the smells, can be dangerous or life-threatening, the clinic’s design controls airflow from room to room, allowing several patients to be seen and evaluated at the same time.

“We also have more control over preparing the foods that is essential when it comes to certain types of foods, or developing challenges where we want to be able to hide the food in certain otherness kinds of food and feed it to the patient without them knowing they’re getting it,” says McMorris.

Allergy facts

An allergen is any substance that causes an allergic reaction. Having a food hypersensitivity reaction means your body’s immune system mistakenly believes the food is harmful.

Food allergies can be more severe than airborne allergies because the food is ingested and then absorbed throughout the body. Airborne allergies are filtered by the eyes or nose, so they don’t enter the body’s system so completely.

The number of group with food allergies is increasing. Experts believe the number has doubled in the past 10 years. There are about 12 mil. Americans with food allergies, and as many as five to 8 % of children under age 3 have food allergies.

There are several theories about why the number of group with allergies is increasing:

– Experts believe this may be due to the way we process our foods. For example, in the United States, peanuts are dry roasted. This makes the compound found in peanuts that triggers an allergic reaction more easily exposed to the immune system.

– Some experts say American children are so well-protected from infection that the immune system, not needing to work as hard to fight infections, switches its focus to allergens, the foreign substances the body attacks in an allergic reaction.

– Heredity might play a role, too. If your parents are allergic, then you’re more likely to have allergies. If one parent has allergies, as many as 50 % of their children also will have allergies. If both parents have allergies, there’s as much as a 70 to 80 % risk that their children will develop allergies of some sort.

What to watch for

The top high-risk foods in this country are milk, eggs, peanuts, tree nuts, fish, shellfish and, recently, sesame seeds.

Food allergies can be life threatening. Reactions range from a few hives to a mild skin reaction to a life-threatening severe reaction.

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Researchers in the UK are eager to find out whether blood-sucking worms - hookworms - might have an effect on the immune system and be used for effective treatment for asthma and other allergies. Researchers from the University of Nottingham say these worms may even have therapeutic benefits for patients with diabetes type 1 and multiple sclerosis.

The researchers explain that for over 30 years data has indicated that individuals infected with tropical hookworms never seem to suffer from allergies. It might not be a coincidence that asthma is virtually completely absent in areas where hookworms are found, but growing where they are not.

People of African descent who live in developed countries suffer from Crohn’s disease, while Africans living in Africa, where these worms are much more common, hardly ever do.

Scientists believe hookworms force their host’s immune system to work less actively. Humans with over-active immune systems suffer from allergies, such as asthma and Crohn’s disease, much more commonly than people whose immune systems are not over-active.

Dr David Pritchard and team are carrying out experiments to find out whether hookworms can be useful in the treatment of auto-immune diseases (over-active immune systems).

– “The Worm That Turned” - Nottingham University

What is a Hookworm?

A hookworm is a parasite - a parasitic nematode worm - that exists in the small inagsdhfgdfine of the host. The host may be any type of several mammals, including humans. There are two types that typically infect human beings:

– Ancylostoma duodenale: Found in the Middle East, North Africa, India and Europe.

– Necator americanus: Found in the Americas, Sub-Saharan Africa, Southeast Asia, China and Indonesia.

It is estimated that about 800 million people are infected with hookworms globally.

A person who is infected may experience anemia. The worms are insatiable blood-suckers and damage the mucosa (in the gut). Loss of blood is not possible by inspecting the stools; you cannot see the blood loss by checking the patient’s excrements.

Hookworms are a major cause of child and maternal morbidity in the tropical and subtropical regions of the developing world. They can cause intellectual, cognitive and growth retardation in vulnerable children, as well as intrauterine growth retardation, prematurity, and low birth weight.

Even though infection is hardly ever fatal, a heavily infected person can experience considerable health problems.

Written by: Christian Nordqvist
Copyright: Medical News Today
Not to be reproduced without permission of Medical News Today

Researchers at the National Institutes of Health (NIH) have found that more than 50 percent of the current asthma cases in the country can be attributed to allergies, with approximately 30 percent of those cases attributed to cat allergy.

“It has long been debated whether people who develop asthma have a genetic propensity to develop allergies, or atopy,” said Darryl C. Zeldin, M.D., a senior investigator at the National Institute of Environmental Health Sciences (NIEHS). “This new research shows that 56.3 percent of asthma cases are attributed to atopy.” Atopy is a condition that results from gene-environment interactions and can be measured by a positive skin agsdhfgdf to allergens (or allergy causing substances in the environment).

The study, available online in the Journal of Allergy and Clinical Immunology, was conducted by researchers at the National Institute of Environmental Health Sciences (NIEHS) and the National Institute of Allergy and Infectious Diseases, both parts of the NIH. The data come from the Third National Health and Nutrition Examination Survey (NHANES III), a nationally representative sample of the population of the United States.

“Sensitization to cat appears to be a strong risk factor for asthma in this study,” said Zeldin. Zeldin and his co-authors, however, point out that some research shows that exposure to cats, particularly early in life, may be a protective factor. “We are not advocating parents get rid of pets, but if you suspect that you or your child might have cat allergies or get asthmatic-like symptoms, you should consult with a physician about the best course of action for your family,” added Zeldin.

The NIH researchers looked at skin agsdhfgdf data for ten allergens. A positive skin agsdhfgdf reaction to cat allergens accounted for 29.3 percent of the asthma cases, followed by the fungus Alternaria at 21.1 percent and white oak at 20.9 percent. “Each of 10 allergen-specific skin agsdhfgdfs was strongly associated with asthma; however, after adjustment by a variety of subject characteristics and all the allergens, only skin agsdhfgdfs to cat, Alternaria and white oak were independently and positively associated with asthma,” said Peter Gergen, M.D., M.P.H, of NIAID’s Division of Allergy, Immunology and Transplantation, a co-author on the paper.

Other allergens agsdhfgdfed include: Ragweed, dustmites, Russian thistle, Bermuda grass, peanuts, perennial rye and german cockroach. Approximately 10,500 individuals participated in the skin agsdhfgdfing. During these agsdhfgdfs, skin was exposed to allergy-causing substances (allergens) and a positive agsdhfgdf was determined by the size of the reaction on the skin.

“This study tells us that allergy is a major factor in asthma,” Gergen said. “But this study also tells us is that there are many people who get asthma who don’t have allergies. We need to do more research to understand what is causing the asthma that is not related to allergies.”

“This study confirms that the environment plays a major role in the development of asthma,” said Zeldin. “Given the complexity of this disease it won’t be easy, but if we can prevent, block or reverse atopy, we could reduce a large proportion of asthma cases.”

The National Institute of Environmental Health Sciences (NIEHS), a component of the National Institutes of Health, supports research to understand the effects of the environment on human health. For more information on environmental health topics, please visit our website at http://www.niehs.nih.gov.

NIAID is a component of the National Institutes of Health, an agency of the U.S. Department of Health and Human Services. NIAID supports basic and applied research to prevent, diagnose and treat infectious diseases such as HIV/AIDS and other sexually transmitted infections, influenza, tuberculosis, malaria and illness from potential agents of bioterrorism. NIAID also supports research on transplantation and immune-related illnesses, including autoimmune disorders, asthma and allergies.

The National Institutes of Health (NIH) - The Nation’s Medical Research Agency - includes 27 Institutes and Centers and is a component of the U.S. Department of Health and Human Services. It is the primary federal agency for conducting and supporting basic, clinical and translational medical research, and it investigates the causes, treatments, and cures for both common and rare diseases. For more information about NIH and its programs, visit http://www.nih.gov.

Reference: Arbes SJ, Gergen,PJ Vaughn B, Zeldin DC. Asthma cases attributable to atopy: Results from the Third National Health and Nutrition Examination Survey. Journal of Allergy and Clinical Immunology. September, 2007.

Seafood allergy sufferers may soon be able to eat prawns without the fear of an adverse reaction. Chinese scientists have taken a promising step towards removing from prawns the proteins that cause an allergic response without resorting to genetic manipulation, reports Lisa Richards in Chemistry & Industry, the magazine of the SCI.

Li Zhenxing led the research at the Ocean University of China. The team revealed that treating prawns with a combination of heat and irradiation significantly reduced the level of reactive proteins called allergens. They took blood from patients with shrimp allergies, added samples of treated and untreated prawn, and measured how antibodies in the blood reacted. They found that levels of ‘Pen a 1′, one of the major allergens, decreased 20-fold after treatment (Journal of the Science of Food and Agriculture DOI 10.1002/jsfa.2746).

Zhenxing’s team suggests that irradiation damages the proteins, revealing hidden reactive amino acid residues. Subsequent heating then destroys the exposed residues. “Radiation and heat seems to be a promising method for reducing the immunoreactivity” say the researchers.

Samuel Lehrer of Tulane University in New Orleans, USA, is already working on removing allergens from prawns using genetic techniques. But Zhenxing’s method could be preferable for people wary of eating genetically modified foods.

—————————-
Article adapted by Medical News Today from original press release.
—————————-

Please acknowledge Chemistry & Industry as the source of these items.

About Chemistry & Industry

Chemistry & Industry magazine from SCI delivers news and comment from the interface between science and business. As well as covering industry and science, it focuses on developments that will be of significant commercial interest in five- to ten-years time. Published twice-monthly and free to SCI Members, it also carries authoritative features and reviews. Opinion-formers worldwide respect Chemistry & Industry for its independent insight.

About the Journal of the Science of Food and Agriculture

The Journal of the Science of Food and Agriculture (JSFA) publishes peer-reviewed original research and critical reviews in these areas, with particular emphasis on interdisciplinary studies at the agriculture/food interface. This international journal covers fundamental and applied research.

JSFA is an SCI journal, published by John Wiley & Sons, on behalf of the Society of Chemical Industry, and is available in print (ISSN: 0022-5142) and online (ISSN: 1097-0010) via Wiley InterScience http://www.interscience.wiley.com/ For further information about the journal go to http://interscience.wiley.com/jsfa

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SCI is a unique international forum where science meets business on independent, impartial ground. Anyone can join, and the Society offers a chance to share information between sectors as diverse as food and agriculture, pharmaceuticals, biotechnology, environmental science and safety. As well as publishing new research and running events, SCI has a growing database of member specialists who can give background information on a wide range of scientific issues. Originally established in 1881, SCI is a registered charity with members in over 70 countries.

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